OPG, Human

$120.00

Osteoprotegerin

Brand	TECOmedical

SKU: RD194003200 Category: Bone metabolism

Description
Specifications

Description

Intended use:

Osteoprotegerin (OPG) is a secretory glycoprotein belonging to the TNF receptor super family. OPG inhibits the binding of RANK to RANKL and thus inhibits the recruitment, proliferation and activation of osteoclasts. Since OPG exhibits an inhibitory effect on osteoclasts activation, it acts as a soluble factor in the regulation of bone mass. Changes in the homeostasis of the RANKL/RANK/OPG systems causes disturbances in bone remodeling shown by bone damages in patients with postmenopausal osteoporosis, Paget’s disease, bone loss due to cancer metastases and rheumatoid arthritis.

Intended applications:

Postmenopausal and senile osteoporosis
Glucocorticoid dependent osteoporosis
Diseases with locally increased resorption activity
Therapy control of OPG treatments
Arthritis
Bone metastases
Vascular calcification
Renal cell carcinoma

Specifications

Range:	1.5 – 60 pmol/l
Sensitivity:	Analytical: 0.13 pmol/l; Assay: 0.4 pmol/l
Incubation time:	3 hours
Sample volume:	100 µl (dilute 1:3, cell culture direct)
Sample type:	Serum, plasma (EDTA, Citrate, Heparin), cell culture, synovial fluid.
Sample preparation:	No activity loss for 8 hours at room temperature or up to 2 weeks at4 °C. Store samples at -20 °C for longer storage. Serum is stable up to 3 freeze and thaw cycles, Heparin only stable for 1 freeze and thaw cycle. Before use, thaw samples at low temperature and mix them thoroughly. Hemolyzed or lipemic sera may cause erroneous results.
Reference values:	Average 5.7 ± 0.42 pmol/l
Species:	Human, baboon, rhesus macaque.
Tests:	96 Tests
Method:	ELISA

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