Description
Intended use: |
Quantitative measurement of the apoptotic cell death biomarker K18-Asp396-NE in cell culture experiments. Can be used for cell lysates and/or culture supernatants. The assay only detects apoptosis in cells of epithelial origin that express K18. Cells should be of human, monkey or bovine origin. To be used to determine accumulation of caspase-cleaved K18 (ccK18) in cell cultures, providing an integrative measure of apoptosis. The K18-Asp396 neo-epitope is formed by caspase-3, -7 or -9 activation. *Note: caspase-cleaved K18 = ccK18 previously Cytokeratin 18 (CK18/ccCK18) |