Intended use:
Dickkopf-1(DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signaling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression.
DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumorigenic activity.
Intended applications:
- Atherosclerosis
- Rheumatoid arthritis
- Myeloma bone disease
- Diffuse idiopathic skeletal hyperostosis
- Ankylosing spondylitis
- Monoclonal gammopathy of undetermined significance
- Glucocorticoid induced osteoporosis
- Oncology
