| Intended use: |
CS-846, a chondroitin sulfate epitope, which is normally only present on intact aggrecan “fetal-like” proteoglycan, is used as a biomarker in the investigation of the cartilage synthesis/turnover in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and cartilage injury and repair in human as well as some animal models. |
| Range: | 20-1000 ng/mL |
| Incubation time: | 3 hours |
| Sample volume: | 10 μl (dilute 1:5) |
| Sample type: |
Serum (also used for synovial fluid, cell culture, cartilage extract) |
| Sample preparation: |
Serum samples should be aliquoted, rapidly frozen and stored at -70 °C. Avoid repeated freezing/thawing of samples. |
| Species: |
Human (also used for horse, bovine, dog, rabbit, guinea pig, rat, rhesus macaque, sheep). The use of mouse samples may lead to high background interference. |
| Cross reaction: |
Chondroitin sulfate, dermatan sulphate and keratan sulfate alone, either in their native or degraded state, show no reactivity. |
| Tests: | 96 Tests |
| Method: | ELISA |