Description
Human C9 is a soluble glycoprotein of 61 kD. It is the last component in the assembly of the membrane attack complex (MAC). When the complement is activated on target membranes, multiple copies of C9 bind to the C5b-8 complex and assemble the barrel-shaped pore which causes cell lysis. The conformation of C9 changes from globular to a tubular form. The binding of C9 to C5b-8 plays a key role in the function of C9.
References
1. Hatanaka, M et al; Analysis of C5b-8 binding sites in the C9 molecule using monoclonal antibodies: participation of two separate epitopes of C9 in C5b-8 binding. Mol Immunol 1992, 29: 911
Specifications
Volume: 1 ml
Amount: 100 µg
Formulation: 0.2 µm filtered in PBS+0.1%BSA
Concentration: 100 µg/ml
Host Species: Mouse IgG1
Conjugate: None
Endotoxin: <24 EU/mg
Purification: Protein G
Storage: 4°C
Safety and Handling
Storage & stability:
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Precautions:
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product
