C3c Human clone 4

$139.00

The monoclonal antibody 4 recognizes the cleaved human C3 fragment C3c.

Brand

SKU: TE2200-100UG Category:

Description

The monoclonal antibody 4 recognizes the cleaved human C3 fragment C3c. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. The synthesis of C3 is tissue specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. An inherited deficiency of C3 predisposes the person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by C3-convertases results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. The monoclonal antibody 4 recognizes a conformational epitope in C3c, C3b and iC3b.

Specifications

Volume:                    1 ml

Amount:                   100 µg

Formulation:            0.2 µm filtered in PBS+0.1%BSA+0.02%NaN3

Concentration:        100 µg/ml

Host Species:          Rat IgG2a

Conjugate:               None

Endotoxin:               N.A.

Purification:            Protein G

Storage:                   4°C

Safety and Handling

 

Storage & stability

Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.

Precautions

For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not

responsible for any patent infringements that might result from the use or derivation of this product.

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